Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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3,676 – 3,690 of 5,327 results

3,676

Medchemexpress LLC Amelparib hydrochloride | 98.4% | 379.88 | 1 MG

Amelparib hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. It inhibits PARP-1 activity (IC50 = 18.5 nM) and cellular PAR formation (IC50 = 10.7 nM). This compound is a potential neuroprotective agent and has potential for the research of acute ischaemic stroke.

Potent, orally active, and water-soluble inhibitor of PARP-1
Inhibits PARP-1 activity (IC50 = 18.5 nM)
Inhibits cellular PAR formation (IC50 = 10.7 nM)
Potential neuroprotective agent
Potential for research of acute ischaemic stroke
Appearance: Solid
Color: Off-white to light yellow

Pricing & Availability

3,677

ALADDIN SCIENTIFIC CORPORATION Ninhydrin, 5g

Used in the detection and assay of peptides amino acids amines and amino sugars yielding highly fluorescent ternary compounds with aldehydes and primary amines Reaction with sarcosine or proline gives azomethine ylides Application It can be used for the detection of peptides amino acids amino acids and amino sugars and can produce strong fluorescent ternary compounds with aldehydes and primary amines Reacts with sarcosine or proline to form methylimine Ylide Ninhydrin (ninhydrin hydrate) can be used as a reagent for the determination of amino acids and peptides by photometry and colorimetry It can also be used to prepare ninhydrin reagents by mixing ninhydrin with hydroninhydrin (reduced form of ninhydrin) in dimethyl sulfoxide This reagent can be used for the manual ninhydrin method to quantify amino acids It can be used to detect free amino groups in amino acids peptides and proteins

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3,678

Medchemexpress LLC Alfuzosin (hydrochloride) | 81403-68-1 | 99.7% | 25 MG

Alfuzosin hydrochloride is an orally active, selective, and competitive α1-adrenoceptor antagonist. It relaxes the muscles of the prostate and bladder neck, aiding in urination. This compound is used in the study of benign prostatic hyperplasia (BPH).

Orally active compound
Selective and competitive α1-adrenoceptor antagonist
Relaxes prostate and bladder neck muscles
Aids in urination
Used for benign prostatic hyperplasia (BPH) studies

Pricing & Availability

3,679

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 25 MG

Eperisone Hydrochloride is an orally active antispastic agent that also exhibits a vasodilator effect. It is used in research for muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist and also shows antagonism for human P2X3. Eperisone Hydrochloride functions by relaxing both skeletal and vascular smooth muscles, leading to various effects such as reduced myotonia, improved circulation, and suppression of the pain reflex.

Antispastic agent
Vasodilator effect
P2X7 receptor antagonist
P2X3 antagonist
Muscle relaxation
Therapeutic effects
Research use only

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3,680

Medchemexpress LLC Lidocaine hydrochloride | 73-78-9 | 99.8% | 5 G

Lidocaine hydrochloride (Lignocaine hydrochloride) is an amide derivative that inhibits sodium channels. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. It is used to treat ventricular arrhythmia and is an effective tumor-inhibitor.

Decreases cell proliferation
Inhibits cell viability
Increases the apoptotic cell rate
Down-regulates Cyclin D1 and up-regulates p21 expression
Causes completely reversible tail nerve block in rats

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3,681

Medchemexpress LLC Riviciclib hydrochloride | 920113-03-7 | 99.08% | 438.30 | 25 MG

Riviciclib hydrochloride is a potent cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively. This compound shows antitumor activity on cisplatin-resistant cells.

IC50 & Target information available
In vitro studies show activity in various cancer cell lines
In vivo studies demonstrate significant inhibition of tumor growth

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3,682

Medchemexpress LLC SGK1-IN-3 hydrochloride | 96.7% | C23H21Cl3N6O3S | 25 MG

SGK1-IN-3 hydrochloride is a potent SGK1 inhibitor with an IC50 of less than 1 μM. It has the potential for the research of osteoarthritis.

Potent SGK1 inhibitor with an IC50 of <1 μM
Potential for osteoarthritis research

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3,683

Medchemexpress LLC GB111-NH2 hydrochloride | 99.3% | 610.14 | 100 MG

GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor and can be used for cancer study.

Functions as a cysteine cathepsin inhibitor
Suitable for cancer research
Chemical formula C33H40ClN3O6
Appears as a solid, white to off-white powder
Soluble in DMSO at 125 mg/mL (in vitro)
Soluble in 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline at 5 mg/mL (in vivo)
Classified under metabolic enzyme/protease and cathepsin

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3,684

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 50 MG

Dopexamine hydrochloride is a β2 adrenergic receptor agonist and dopamine analogue. It acts on β2 and dopaminergic receptors to attenuate systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury. This compound helps reduce inflammation, cytokine release, endothelial adhesion molecules, and oxidative stress without significantly altering blood pressure or stroke volume.

Attenuates systemic inflammatory response
Reduces tissue leukocyte infiltration
Protects against organ injury
Reduces systemic inflammatory response to endotoxin
Reduces cytokine release
Reduces endothelial adhesion molecules
Reduces oxidative stress
Does not substantially change systemic hemodynamics

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3,685

Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.58% | 437.90 | 50 MG

Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

Inhibits topoisomerase II activity.
Induces site-selective DNA DSB.
Causes G2 arrest.
Leads to apoptosis.
Shows potent cytotoxic activity in AML cell lines.
Exhibits additive or synergistic activity with cytarabine in acute leukemia cell lines.
Reduces bone marrow cellularity in mice.
Causes reversible decrease in myeloid and lymphoid cells in vivo.

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3,686

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 25 MG

Donepezil Hydrochloride is a reversible, selective acetylcholinesterase (AChE) inhibitor with an IC50 of 6.7 nM. It demonstrates high selectivity for AChE over butyrylcholinesterase (BuChE) and offers neuroprotective effects against Aβ42 neurotoxicity. Its mechanism involves enhanced phosphorylation of Akt and GSK-3β, alongside reduced phosphorylation of tau and glycogen synthase.

Reversible, selective AChE inhibitor
High selectivity for AChE over BuChE
Neuroprotective effects on Aβ42 neurotoxicity
Enhances phosphorylation of Akt and GSK-3β
Reduces phosphorylation of tau and glycogen synthase
Prevents scopolamine-induced memory impairment in mice
Increases cell viability in cortical neuronal cells

Pricing & Availability

3,687

Medchemexpress LLC Amrubicin hydrochloride | 110311-30-3 | 98.78% | C25H26ClNO9 | 5 MG

Amrubicin hydrochloride (SM-5887) is a DNA topoisomerase II inhibitor used for cancer research. It exhibits radio-enhancement effects on human lung adenocarcinoma A549 cells and suppresses various other cell lines. It also induces apoptosis in U937 cells and demonstrates significant antitumor activities against SCLC tumors in vivo.

DNA topoisomerase II inhibitor.
Used for research of cancer.
Exhibits radio-enhancement effects on human lung adenocarcinoma A549 cells.
Suppresses LX-1, A549, A431, and BT-474 cell lines.
Induces apoptosis in U937 cells and activates caspase-3/7.
Reduces mitochondrial membrane potential (Δψm).
Demonstrates significant antitumor activities against SCLC tumors.
In combination with cisplatin and irinotecan, it significantly inhibits tumor growth.
Suppresses tumor growth in human cancer xenograft models.

Pricing & Availability

3,688

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 100 MG

Alosetron Hydrochloride is a potent and highly selective serotonin 5-HT3 receptor antagonist used in research for irritable bowel syndrome (IBS). It blocks the fast 5HT3-mediated depolarization of guinea-pig myenteric and submucosal neurons, with an IC50 of approximately 55 nM. It also attenuates visceral nociceptive effects of rectal distension in dogs and demonstrates anti-inflammatory properties.

Potent and highly selective serotonin 5-HT3 receptor antagonist
Applicable for research in irritable bowel syndrome (IBS)
Blocks fast 5HT3-mediated depolarization of guinea-pig myenteric and submucosal neurons, with an IC50 of approximately 55 nM
Attenuates visceral nociceptive effects of rectal distension in dogs
Demonstrates anti-inflammatory effects

Pricing & Availability

3,689

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.63% | C17H19ClN4O | 50 MG

Alosetron Hydrochloride is a potent and highly selective antagonist of the serotonin 5-HT3 receptor. It is researched for its application in irritable bowel syndrome (IBS). The compound effectively blocks the rapid 5HT3-mediated depolarization in guinea-pig myenteric and submucosal neurons, with an IC50 of approximately 55 nM. It also demonstrates an ability to lessen the visceral nociceptive effects of rectal distension in conscious or anesthetized dogs, and exhibits anti-inflammatory properties.

Highly selective antagonist of the serotonin 5-HT3 receptor.
Under investigation for irritable bowel syndrome.
Blocks 5HT3-mediated depolarization.
Attenuates visceral nociceptive effects.
Exhibits anti-inflammatory effects.

Pricing & Availability

3,690

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 50 MG

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, reducing H3K79me2 and H3K79me1 levels and down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells, promoting their differentiation and apoptosis, making it useful for leukemia research.

Target: histone methyltransferase; apoptosis
Pathway: epigenetics; apoptosis
Potent and selective DOT1L inhibitor (IC50 of 0.4 nM)
Reduces H3K79me2 and H3K79me1 levels, down-regulating HOXA9 and MEIS1 expression
Selectively inhibits MLL rearrangement cells, promoting differentiation and apoptosis
Well tolerated in vivo with no overt toxicity observed

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Alcohols and polyols

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Medchemexpress LLC Amelparib hydrochloride | 98.4% | 379.88 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alfuzosin (hydrochloride) | 81403-68-1 | 99.7% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lidocaine hydrochloride | 73-78-9 | 99.8% | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Riviciclib hydrochloride | 920113-03-7 | 99.08% | 438.30 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SGK1-IN-3 hydrochloride | 96.7% | C23H21Cl3N6O3S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GB111-NH2 hydrochloride | 99.3% | 610.14 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.58% | 437.90 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amrubicin hydrochloride | 110311-30-3 | 98.78% | C25H26ClNO9 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.63% | C17H19ClN4O | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More